Info for UM Clinicians

Most comprehensive prognostic test:
UMtestgraphic-30Mar2016-2

Reports: We strive to provide as much useful information as possible. World-renowned medical experts contribute to cases involving complex interpretation.

Re-tests: If no mutation is found, we bank any remaining DNA. In the future, when new science or test methods are available, we will contact referring specialists to offer to re-test. For any new findings, we re-issue our report at no added charge.

Clinically appropriate turn-around time: Turn-around time is 3 to 6 weeks.

Certified lab: Our lab is fully accredited by the Ontario Lab Accreditation (OLA) Program and College of American Pathologists (CAP), registered under CLIA ‘88 legislation and compliant with ISO 15189:2012. We are a member of the European Molecular Quality Network (EMQN).

Service excellence: Impact is committed to exceptional customer service. Our team provides test order support so you can spend more time with your patients.

Logistics: Impact provides genetic testing services to about 25 countries and samples are routinely shipped from across the world without disruption. We provide the necessary paperwork and recommend a courier service that will reliably deliver the samples.

Impact Genetics’ Uveal Melanoma Test Description

  • Copy number testing using MLPA on chromosomes 1p, 3, 6 and 8 to detect monosomy, disomy and trisomy.
  • Microsatellite analysis (MSA) on chromosome 3 to detect loss of a chromosome copy and isodisomy.
  • Sequencing GNAQ and GNA11 to detect frequently occurring mutations in UM tumor for confirmation of tumor sampling.

Sample requirements

  • 200 ng of DNA is preferred. Testing may be possible on less than 100 ng of DNA.
  • Tumor samples for DNA analysis can be fresh or frozen. Samples can be safely sent with up to 2 days in transit.
  • A biopsy may be taken at the time of plaque insertion or on the last day of proton beam radiotherapy.
  • A biopsy may be taken from an enucleated eye.

 

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